Endocrine Abstracts

Introduction: Primary hyperaldosteronism is a known cause for secondary hypertension. In addition to its effect on blood pressure, aldosterone exhibits proinflammatory actions and plays a role in immunomodulation of autoimmunity. Autoimmune hyperthyroidism (Graves’ disease) and primary hyperaldosteronism rarely coexist but underlying mechanisms associating the two are still unclear.Case report: A 32-year-old female referred to endocrine unit for fur...

Introduction: Clinical manifestations of hypocalcaemia vary from very mild and asymptomatic biochemical abnormality to severe life-threatening disorders. Heart failure due to hypocalcaemia is refractory to conventional treatment. Many clinicians may be unaware of hypocalcaemia associated with heart failure, since it is often ignored. Hypocalcaemia heart failure is a rare and potentially reversible disturbance, The decompensated heart failure is rapidly reversed by aggressive c...

Background: The frequency of prediabetes is increasing as the prevalence of obesity rises worldwide. Hyperglycemia, insulin resistance, inflammation and metabolic derangements associated with concomitant obesity cause endothelial dysfunction in prediabetics, leading to increased risk of cardiovascular and renal disease.Objective: To get a general perspective on the complex relationship between cardiovascular diseases onset, and pre–diabetes<p c...

Introduction: Amyloidosis refers to a variety of conditions in which amyloid proteins are abnormally deposited in organs and/or tissues. Clinically significant enlargement of the thyroid owing to amyloid deposition is a rare occurrence.Case report: 58-year-old female referred to endocrinology clinic presenting with increasing dyspnea, dysphagia and visible swelling at the base of the neck for the last 6 months. She had been diagnosed with rheumatoid arth...

Introduction: Papillary thyroid carcinoma is the most common type of thyroid cancer (70-80% of all thyroid cancer). It is a differentiated type of carcinoma, it affects women between 30-60 years old, 3 times more often than males. Clinical outcome in patients with differentiated thyroid carcinoma is often favorable. Glucocorticoids (GC) play major role in the physiologic stress response. However chronic exposure to glucocorticoids as seen in Cushing’s disease (CD) has det...

Introduction: Haematologic involvement is not uncommon in Graves’ disease. Autoimmune haemolytic anaemia is occasionally reported in patients with other autoimmune illnesses. However very rarely reported in Graves’ disease.Case report: We report a 19-year-old female with reactive arthritis, Graves’ disease and autoimmune haemolytic anaemia while under treatment with methimazole. Physical examination: Under built female BMI 17, Blood pressu...

Introduction: Bardet–Biedl syndrome (BBS) is a rare genetic ciliopathy with a prevalence of 1 in 160,000 in Europeans and 1 in 13,500 in some Arab populations The primary clinical features of BBS include retinal dystrophy, obesity, postaxial polydactyly, renal dysfunction, learning difficulties, and hypogonadism. Traditionally, BBS is clinically diagnosed when a patient shows 4 primary featuresCase report: 17 year old male, single, worker, presented...

Introduction: Hashimoto’s encephalopathy is a neurological disorder of unknown cause associated with thyroid autoimmunity. It is easy to misdiagnose or overlook and the symptoms frequently lead to mistaken neurological diagnoses. The disease may present in two types – a sudden vasculitic type or a progressive subacute type associated to cognitive dysfunction, confusion and memory loss.Case report: A 34 year old male presented to our emergency d...

Introduction: Mast cells are critical effectors in inflammatory diseases, including cardiovascular and metabolic diseases and their associated complications. These cells exert their physiological and pathological activities by releasing granules containing histamine, cytokines, chemokines, and proteases, including mast cell-specific chymases and tryptases.Aim of the study: To detect the role of mast cell in diabetic obese and correlation to different dia...

Introduction: Iodine is needed for the production of thyroid hormone. The prediction of iodine intake is difficult. The standard measure of iodine nutrition in a community is the median urinary iodine excretion, expressed in micrograms per liter. According to the WHO, a median urinary iodine excretion of 100–199 μg/l indicates that the iodine intake is adequate.The aim of this work is to measure the iodine excretion in patients with thyroid nod...